Adelbert Bacher Selected Research

6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)

5/2010	Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.
8/2009	Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
4/2008	A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.
9/2007	Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.
10/2006	Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
3/2005	Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.

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Adelbert Bacher Research Topics

Disease

10	Tuberculosis (Tuberculoses) 10/2013 - 11/2004
8	Malaria 02/2015 - 02/2002
3	Infections 09/2019 - 08/2008
3	Communicable Diseases (Infectious Diseases) 01/2017 - 08/2008
1	Listeriosis (Listeria Infection) 09/2019
1	Rare Diseases (Rare Disease) 09/2019
1	Toxoplasmosis 01/2015
1	Neoplasms (Cancer) 10/2009
1	Inflammation (Inflammations) 10/2009
1	Starvation 08/2004
1	Ganglion Cysts (Ganglion) 02/2002

Drug/Important Bio-Agent (IBA)

8	EnzymesIBA 01/2017 - 02/2002
6	Terpenes (Terpenoids)IBA 01/2017 - 01/2008
6	6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)IBA 05/2010 - 03/2005
5	Mevalonic Acid (Mevalonate)IBA 02/2014 - 02/2002
3	Pharmaceutical PreparationsIBA 02/2015 - 05/2003
2	HerbicidesIBA 01/2017 - 02/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2009 - 03/2005
2	Riboflavin SynthaseIBA 08/2009 - 09/2007
1	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 09/2019
1	ProdrugsIBA 02/2015
1	Antimalarials (Antimalarial Agents)IBA 02/2015
1	Atovaquone (Mepron)FDA Link 01/2015
1	Pentamidine (NebuPent)FDA LinkGeneric 01/2015
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 01/2015
1	Oxidoreductases (Dehydrogenase)IBA 06/2014
1	fosmidomycinIBA 10/2013
1	artemisinin (artemisinine)IBA 02/2010
1	alanylaspartic acidIBA 08/2008
1	Glucose (Dextrose)FDA LinkGeneric 08/2008
1	glycyl-threonineIBA 08/2008
1	Bacterial Proteins (Bacterial Protein)IBA 08/2008
1	IsotopesIBA 08/2008
1	Schiff Bases (Schiff Base)IBA 04/2008
1	Phosphates (Orthophosphate)IBA 04/2008
1	RNA (Ribonucleic Acid)IBA 11/2004
1	Proteins (Proteins, Gene)FDA Link 08/2004

Therapy/Procedure

1	Hematopoietic Stem Cell Transplantation 01/2015
1	Therapeutics 02/2010
1	Drug Therapy (Chemotherapy) 10/2009